Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C1QA, C3, CX3CR1, CX3CL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | associated_with | disease | 0.50 |
| HIF1A, NFKB1 | co_associated_with | gene | 0.40 |
| CLOCK, ARNTL | co_associated_with | gene | 0.40 |
| IL1B, TNFA, NLRP3 | co_associated_with | gene | 0.40 |
| IGFBPL1 | co_associated_with | gene | 0.40 |
| DNMT3A, HDAC1/2 | co_associated_with | gene | 0.40 |
| GPR43, GPR109A | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Synaptic Pruning Precision Therapy | 0.465 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.513
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Young adult microglial deletion of C1q reduces engulfment of synapses and preven [PMID:41000995] | Petrisko TJ, Chu SH, Gomez-Arboledas A, | bioRxiv : the preprint server | 2025 | 1 |
| Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-med [PMID:40731189] | Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S, | Alzheimer's & dementia : the j | 2025 | 1 |
| Trigeminal neuralgia. [PMID:38816415] | Ashina S, Robertson CE, Srikiatkhachorn | Nature reviews. Disease primer | 2024 | 1 |
| Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455] | Cornell J, Salinas S, Huang HY, Zhou M | Neural Regen Res | 2022 | 1 |
| The Role of Complement in Synaptic Pruning and Neurodegeneration. [PMID:34595138] | Gomez-Arboledas A, Acharya MM, Tenner AJ | ImmunoTargets and therapy | 2021 | 1 |
| Opioid Receptors. [PMID:26332001] | Stein C | Annual review of medicine | 2016 | 1 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
Multi-agent debates referencing this entity